Characterization of botulinum neurotoxin type A subtypes by immunocapture enrichment and liquid chromatography–tandem mass spectrometry
نویسندگان
چکیده
منابع مشابه
Botulinum Neurotoxin Detection and Differentiation by Mass Spectrometry
Botulinum neurotoxins (BoNTs) are proteases that cleave specific cellular proteins essential for neurotransmitter release. Seven BoNT serotypes (A-G) exist; 4 usually cause human botulism (A, B, E, and F). We developed a rapid, mass spectrometry-based method (Endopep-MS) to detect and differentiate active BoNTs A, B, E, and F. This method uses the highly specific protease activity of the toxins...
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ژورنال
عنوان ژورنال: Analytical and Bioanalytical Chemistry
سال: 2015
ISSN: 1618-2642,1618-2650
DOI: 10.1007/s00216-015-8707-1